Associations between risk of paralytic ileus and atypical antipsychotic use in mixed dementia

Abstract

Dementia affects 35 million people worldwide. Although Alzheimer’s Disease (AD) is the most common form of dementia, 25% of patients have vascular dementia (VaD) and a further 20–40% have mixed dementia with VaD and AD. More than 90% of patients with dementia will experience at least one behavioural and psychological symptoms of dementia (BPSD), such as delusions, hallucinations, agitation and aggression during the course of their condition.  Both atypical and conventional antipsychotics are used in the management of BPSD. However, prescribing trends heavily favour atypical antipsychotics because of a modest advantage with respect to tolerability and safety.

This article wants to present the side effect of atypic antipsychotics in a old female with mixed dementia with behavioural symptoms who developed progressively accentuated transit disorders in the absence of other detectable causes